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**Max Delbrück Center** @MDC_Berlin · Apr 25, 2023 *

Apr 25, 2023 *

70 years ago, Watson and Crick explain a basic principle of life in Nature: #DNA has the structure of a double helix. How the strand of genetic material is packed into the nucleus of a cell is also anything but random.

A on our recent research on DNA
#DNADay
Anton Henssen

**Max Delbrück Center** @MDC_Berlin · Apr 25, 2023 *

Apr 25, 2023 *

Max Delbrück Center @MDC_Berlin

2/5 The fins of skates: The key to their #evolution lies in the non-coding bits of the animals’ #genome and the 3D complexes it folds into: TADs. #mdcBerlin scientist @dariloops is among the lead authors of the @nature paper.
https://www.mdc-berlin.de/news/press/how-skates-learned-fly-through-water
#DNADay #DNADay23

www.mdc-berlin.deHow skates learned to fly through waterGenes are not the only drivers of evolution. The iconic fins of skates are caused by changes in the non-coding parts of the genome and its three-dimensional structure, a research team including Darío Lupiáñez at the Max Delbrück Center reports in “Nature”.

**Max Delbrück Center** @MDC_Berlin · Apr 25, 2023 *

Apr 25, 2023 *

Max Delbrück Center @MDC_Berlin

3/5 Abnormalities in DNA folding presumably cause learning disorders. Ana Pombo and Alexander Kukalev have received a DFG grant to test this hypothesis.
https://www.mdc-berlin.de/news/news/cracking-chromatin-code

www.mdc-berlin.deCracking the chromatin codeChromatin factors are involved in regulating gene expression. If they do not function properly, this can result in neurological impairments. Ana Pombo and Alexander Kukalev are now receiving almost €400,000 from the DFG for a research project that aims to shed more light on how these factors work.

#DNADay #DNADay23

**Max Delbrück Center** @MDC_Berlin · Apr 25, 2023 *

Apr 25, 2023 *

Max Delbrück Center @MDC_Berlin

4/5 Antibodies can "steal" pieces of other #genes: Kathrin de la Rosa (@bih_charite) analyzes how the body creates a diverse set of #antibodies to fight off #infections. Her team reports: It's not just mutations @PNASNews

https://www.mdc-berlin.de/news/press/stolen-dna-strengthens-immune-diversity

www.mdc-berlin.deStolen DNA strengthens immune diversityTo combat pathogens, the immune system needs an enormous number of different antibodies. In an MDC study, a group led by BIH professor Kathrin de la Rosa has now described in the journal PNAS a “stealing” mechanism that contributes to antibody diversity.

#DNADay #DNADay23

Max Delbrück Center @MDC_Berlin@social.bund.de

5/5 Solving the mystery of DNA rings: Anton Henssen and scientists from and research the role that ring-shaped strands of DNA play in the development of #cancer, and how to fight them.

https://www.mdc-berlin.de/news/press/cancer-grand-challenge-henssen

www.mdc-berlin.deCancer Grand Challenge: Solving the mystery of DNA ringsPediatric oncologist Anton Henssen and a group of researchers from the US and the UK have won funding for a Cancer Grand Challenge. The international team will receive almost €24 million to research the role that ring-shaped strands of DNA play in the development of cancer, and how to fight them.

#DNADay #DNADay23

Apr 25, 2023, 03:40 PM··Moa

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