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Modfeel📢 Chapter 2 of <a href="https://mastodon.social/tags/Modfeel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Modfeel</a> now online! 🎉 👉 2. Modeling <a href="https://modfeelblog.wordpress.com" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://modfeelblog.wordpress.com</a>About <a href="https://mastodon.social/tags/models" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#models</a>, <a href="https://mastodon.social/tags/simulations" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#simulations</a> and <a href="https://mastodon.social/tags/predictions" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#predictions</a>. How organisms create <a href="https://mastodon.social/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> models of their environment and use them for simulations and predictions. And the <a href="https://mastodon.social/tags/limits" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#limits</a> of <a href="https://mastodon.social/tags/modeling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#modeling</a>. <a href="https://mastodon.social/tags/NeuronalNetworks" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NeuronalNetworks</a> <a href="https://mastodon.social/tags/Cognition" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cognition</a> <a href="https://mastodon.social/tags/Evolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Evolution</a> <a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biology</a> <a href="https://mastodon.social/tags/Psychology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Psychology</a> <a href="https://mastodon.social/tags/Philosophy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Philosophy</a>

Rupert OverallA really nice review just out on the epigenetic bases of brain ageing and how modulating epigenetics may hold therapeutic potential for treating age-related disorders.<a href="https://doi.org/10.1038/s44318-024-00148-8" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1038/s44318-024-00148-8</a><a href="https://fosstodon.org/tags/epigenetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetics</a> <a href="https://fosstodon.org/tags/aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aging</a> <a href="https://fosstodon.org/tags/ageing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ageing</a> <a href="https://fosstodon.org/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> <a href="https://fosstodon.org/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a>

Fabrizio MusacchioDue to its computational efficiency and biological plausibility, the <a href="https://sigmoid.social/tags/IzhikevichModel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IzhikevichModel</a> is an exceptional tool for understanding <a href="https://sigmoid.social/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> interactions within <a href="https://sigmoid.social/tags/SpikingNeuralNetworks" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SpikingNeuralNetworks</a> (<a href="https://sigmoid.social/tags/SNN" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SNN</a>). Here’s a quick <a href="https://sigmoid.social/tags/Python" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Python</a> implementation of Izhikevich's original <a href="https://sigmoid.social/tags/Matlab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Matlab</a> code along with examples using different synaptic weights and neuron types, each leading to diverse spiking behaviors and network dynamics:🌍<a href="https://www.fabriziomusacchio.com/posts/izhikevich_network_model/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.fabriziomusacchio.com/posts/izhikevich_network_model/</a> <a href="https://sigmoid.social/tags/CompNeuro" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CompNeuro</a> <a href="https://sigmoid.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Neuroscience</a> <a href="https://sigmoid.social/tags/ComputationalScience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ComputationalScience</a> <a href="https://sigmoid.social/tags/NeuralNetworks" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NeuralNetworks</a> <a href="https://sigmoid.social/tags/modeling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#modeling</a>

eLifeResearchers uncover the <a href="https://fediscience.org/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> circuits that let fruit fly larvae control their speed and think this mechanism could help us understand <a href="https://fediscience.org/tags/locomotion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#locomotion</a> in other limbed species. <a href="https://fediscience.org/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://fediscience.org/tags/drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#drosophila</a> <a href="https://elifesciences.org/articles/83328?utm_source=twitter&utm_medium=social&utm_campaign=organic" rel="nofollow noopener noreferrer" target="_blank">https://elifesciences.org/articles/83328?utm_source=twitter&utm_medium=social&utm_campaign=organic</a>

The EMBO JournalER stress induces <a href="https://sciencemastodon.com/tags/caspase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#caspase</a>-2-tBID-GSDME-dependent cell death in neurons lytically infected with <a href="https://sciencemastodon.com/tags/herpes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#herpes</a> simplex <a href="https://sciencemastodon.com/tags/virus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#virus</a> type 2<a href="https://sciencemastodon.com/tags/HSV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HSV</a> type 2 infection promotes <a href="https://sciencemastodon.com/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> <a href="https://sciencemastodon.com/tags/celldeath" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#celldeath</a> and <a href="https://sciencemastodon.com/tags/inflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammatory</a> responses via <a href="https://sciencemastodon.com/tags/ERstress" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ERstress</a>-dependent <a href="https://sciencemastodon.com/tags/gasdermin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gasdermin</a> E activation.Søren Paludan and colleagues<a href="https://www.embopress.org/doi/full/10.15252/embj.2022113118" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2022113118</a>

PLOS BiologyRegulating firing rate. Populations of respiratory <a href="https://fediscience.org/tags/motoneurons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#motoneurons</a> use combinations of 2 activity regulators (Na+ pumps & Kv7 channels) that monitor different readouts of firing rate to maintain <a href="https://fediscience.org/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> output @PellizzariSarah @santin_joe &co <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3Db8oX4" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3Db8oX4</a>

PLOS Biology<a href="https://fediscience.org/tags/Astrocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Astrocytes</a> mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial <a href="https://fediscience.org/tags/pannexin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pannexin</a> 1 channels *inhibits* hippocampal <a href="https://fediscience.org/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> networks - a novel negative feedback loop <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3h65tXQ" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3h65tXQ</a>

PLOS BiologyMicrotubules are key to <a href="https://fediscience.org/tags/axon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#axon</a>-<a href="https://fediscience.org/tags/dendrite" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dendrite</a> polarity, but what determines their correct orientation? @MartinHarterink &co show that local <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> nucleation & stabilization are important for <a href="https://fediscience.org/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> polarity establishment in <a href="https://fediscience.org/tags/Celegans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Celegans</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3EECHX3" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3EECHX3</a>

Lou Zonca<a href="https://fediscience.org/tags/introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#introduction</a>Hi everyone ! I am an applied mathematician working in <a href="https://fediscience.org/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a>! I recently started a postdoc @UniversityPompeuFabra in Barcelona to study disorders of <a href="https://fediscience.org/tags/consciouness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#consciouness</a> (i.e. patients waking up from <a href="https://fediscience.org/tags/coma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coma</a> but not fully recovering) using whole-brain models. I am also interested in neuron-glia interactions and in particular in the role of <a href="https://fediscience.org/tags/astrocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#astrocytes</a> in the regulation <a href="https://fediscience.org/tags/neuronal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuronal</a> activity such as <a href="https://fediscience.org/tags/bursting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bursting</a> and <a href="https://fediscience.org/tags/oscillatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#oscillatory</a> patterns generation.

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